Giang Le Ngoc
Gut microbes and the host are in symbiosis. These gut microorganisms are selected and have been co-evolving with the host. Their functions varied and ranged from energy metabolism to immunity. It is difficult to study this community using common microbiological techniques due to unculturable bacteria. The sequencing of metagenomes can provides additional information to improve current biological knowledge. I am interested in analysing the metagenomic sequencing data to understand about the diversity and ecological role of the gut microbes. Further analysis such as gene annotation, comparative analysis, functional and structural prediction can help to reveal key and novel genes. Bioinformatics helps to visualize and identify the link between host, symbionts, genes and the environment.
Coming from a molecular back ground, I want to combine bioinformatics and molecular techniques to express functional enzymes. Bioinformatics tools help to mine and select genes of interest and molecular techniques help to express and test for enzyme’s activity. I have been working with DNA and sequencing samples from springtails, termites and goats. My current project is to identify, isolate and express proteins with carbohydrate activities for the degradation of hemicellulose. These enzymes can help to breakdown biomass in more natural and sustainable way.
Faddeeva-Vakhrusheva A, Kraaijeveld K, Derks MFL, Anvar SY, Agamennone V, Suring W, Kampfraath AA, Ellers J, Le Ngoc G, van Gestel CAM, Mariën J, Smit S, van Straalen NM & Roelofs D (2017) Coping with living in the soil: the genome of the parthenogenetic springtail Folsomia candida. BMC Genomics. 18: 493.